A prominent feature of science in the twenty-first century lies in the fact that dramatic advances in experimental technology enable us to generate a vast amount of information about complex systems, such as life, earth and environment. Computer - and web - assisted database techniques for extracting useful knowledge from the data are also evolving very rapidly. The Research Organization of Information and Systems (ROIS) was established in 2004, aiming at exploring new vistas in the novel research fields by the joint effort of four research institutes. The direct and integrated collaboration between scientists that produce data by experiments and explorations and that handle the data to extract knowledge will create a new scientific paradigm。